Foundations
Established
Sleep, nutrition and caloric restriction
Daily inputs that shape metabolic aging; the strongest data are for caloric restriction.
How it works
Caloric restriction lowers nutrient-sensing signals such as insulin/IGF-1 and mTOR, which extends lifespan in many animal species. Compounds called CR mimetics aim to trigger similar pathways without eating less.
Hallmarks of aging targeted
Deregulated nutrient sensing · Disabled macroautophagy · Epigenetic alterations
What the evidence says
Honest about what is proven, and what is not.
In the CALERIE randomized trial, 220 adults without obesity assigned to 25% caloric restriction for 2 years showed a slower pace of aging on the DunedinPACE blood test, though effects were small and other clocks such as PhenoAge and GrimAge did not change (Waziry, Nature Aging 2023). That is a biomarker result, not proof of longer healthy life. Compounds marketed as CR mimetics have not shown comparable results in controlled human outcome trials.
Key reference
Waziry R, Ryan CP, Corcoran DL, et al. Nat Aging. 2023;3(3):248-257
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Foundations
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Foundations
Sleep, nutrition and caloric restriction
Daily inputs that shape metabolic aging; the strongest data are for caloric restriction.
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